Does CBD Work with my Supplements?

Sarah M

As the popularity of CBD continues to grow, many people are starting to wonder if it can work in conjunction with their existing supplement routines. But with so many different types of CBD products and dosages on the market, it can be an adventure to figure out which combination works best for you. In this post, we’ll explore how to determine if CBD is compatible with your supplements, and what to consider when adding CBD to your wellness regimen.

How Does CBD Interact with Supplements?

While research on CBD is still ongoing, it’s known that CBD can interact with certain enzymes in the liver, which are responsible for breaking down many substances, including some medications and supplements. This could potentially alter the way these substances are processed in your body, leading to changes in their effectiveness or causing unwanted side effects.

To minimize the risk of negative interactions, it’s essential to consult with a healthcare professional before adding CBD to your supplement routine. They can provide personalized guidance based on your unique needs and the specific supplements you’re taking.

What do I Consider When Adding CBD to my Supplement Routine?

  1. Quality and Purity: As with any supplement, it’s crucial to choose high-quality, independently tested CBD products. Look for reputable brands that use third-party testing to ensure the purity and potency of their products.
  2. Dosage: The appropriate dosage of CBD varies from person to person and depends on factors like weight, metabolism, and the desired effect. Start with a low dose and gradually increase it as needed, keeping in mind that it might take some time to find the right balance.
  3. Timing: Consider when to take your CBD in relation to your other supplements. Some people prefer taking CBD in the morning for an energizing effect, while others take it at night to promote relaxation and sleep. Experiment with different timings to find what works best for you.
  4. Synergy: Look for potential synergistic effects between CBD and your supplements. For instance, combining CBD with supplements that promote relaxation, such as melatonin or magnesium, might enhance their calming effects.
  5. Monitor Your Progress: Keep track of how you feel before and after adding CBD to your supplement routine. This can help you determine if it’s having the desired effect and if any adjustments are needed.
  6. Patience and Consistency: Give CBD time to work and be consistent with your usage. It might take several weeks or even months to notice any significant changes. If you don’t feel any improvement after a reasonable amount of time, it might be worth reconsidering your CBD usage or trying a different product.

Final Thoughts on using CBD with your Supplements.

While CBD has shown promise in supporting various aspects of health and wellness, it’s essential to approach its integration into your supplement routine with care and research. Consult with a healthcare professional, choose high-quality products, and monitor your progress to ensure you’re using CBD safely and effectively alongside your supplements. And remember, every individual’s experience with CBD is unique – what works for someone else may not be the right fit for you. Be patient and open to exploration as you embark on your CBD journey.


  1. Iffland, K., & Grotenhermen, F. (2017). An update on safety and side effects of cannabidiol: A review of clinical data and relevant animal studies. Cannabis and Cannabinoid Research, 2(1), 139-154.
  2. Millar, S. A., Stone, N. L., Yates, A. S., & O’Sullivan, S. E. (2018). A systematic review of cannabidiol dosing in clinical populations. British Journal of Clinical Pharmacology, 84(9), 1888-1900.
  3. Russo, E. B. (2011). Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British Journal of Pharmacology, 163(7), 1344-1364.
  4. Huestis, M. A. (2007). Human cannabinoid pharmacokinetics. Chemistry & Biodiversity, 4(8), 1770-1804.
  5. Grinspoon, P. (2018, August 24). Cannabidiol (CBD) — what we know and what we don’t. Harvard Health Blog.
  6. Zuardi, A. W., Crippa, J. A., Hallak, J. E., Bhattacharyya, S., Atakan, Z., Martin-Santos, R., … & Guimarães, F. S. (2012). A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation. Current Pharmaceutical Design, 18(32), 5131-5140.
  7. The National Academies of Sciences, Engineering, and Medicine. (2017). The health effects of cannabis and cannabinoids: The current state of evidence and recommendations for research. National Academies Press.

Sarah M.

Sarah has a Ph.D in Sociology with a minor in Women’s Studies from the University of Arizona. Her current research spans the fields of trauma, psychology, neurobiology and sociology.

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Vitagenne's products are not for use by or sale to persons under the age of 18 and should be used only as directed on the label. Products should not be used if you are pregnant or nursing. Consult with a physician before use if you have a serious medical condition or use prescription medications. As the consumer, it is your responsibility to know your local, state and federal laws before purchasing products. All products on this website are intended for legal use. Prior to purchasing products on this website, you should confirm legality of the products in the state where you request shipment.
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